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4,142 results on '"Campbell, Lisa"'

4. The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity

Author

Krishnamoorthy, Vidhya, primary, Foglizzo, Martina, additional, Dilley, Robert L., additional, Wu, Angela, additional, Datta, Arindam, additional, Dutta, Parul, additional, Campbell, Lisa J., additional, Degtjarik, Oksana, additional, Musgrove, Laura J., additional, Calabrese, Antonio N., additional, Zeqiraj, Elton, additional, and Greenberg, Roger A., additional

Published
2024
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5. Global oceanic diazotroph database version 2 and elevated estimate of global oceanic N2 fixation

Author

Shao, Zhibo, Xu, Yangchun, Wang, Hua, Luo, Weicheng, Wang, Lice, Huang, Yuhong, Agawin, Nona Sheila R, Ahmed, Ayaz, Benavides, Mar, Bentzon-Tilia, Mikkel, Berman-Frank, Ilana, Berthelot, Hugo, Biegala, Isabelle C, Bif, Mariana B, Bode, Antonio, Bonnet, Sophie, Bronk, Deborah A, Brown, Mark V, Campbell, Lisa, Capone, Douglas G, Carpenter, Edward J, Cassar, Nicolas, Chang, Bonnie X, Chappell, Dreux, Chen, Yuh-ling Lee, Church, Matthew J, Cornejo-Castillo, Francisco M, Detoni, Amália Maria Sacilotto, Doney, Scott C, Dupouy, Cecile, Estrada, Marta, Fernandez, Camila, Fernández-Castro, Bieito, Fonseca-Batista, Debany, Foster, Rachel A, Furuya, Ken, Garcia, Nicole, Goto, Kanji, Gago, Jesús, Gradoville, Mary R, Hamersley, M Robert, Henke, Britt A, Hörstmann, Cora, Jayakumar, Amal, Jiang, Zhibing, Kao, Shuh-Ji, Karl, David M, Kittu, Leila R, Knapp, Angela N, Kumar, Sanjeev, LaRoche, Julie, Liu, Hongbin, Liu, Jiaxing, Lory, Caroline, Löscher, Carolin R, Marañón, Emilio, Messer, Lauren F, Mills, Matthew M, Mohr, Wiebke, Moisander, Pia H, Mahaffey, Claire, Moore, Robert, Mouriño-Carballido, Beatriz, Mulholland, Margaret R, Nakaoka, Shin-ichiro, Needoba, Joseph A, Raes, Eric J, Rahav, Eyal, Ramírez-Cárdenas, Teodoro, Reeder, Christian Furbo, Riemann, Lasse, Riou, Virginie, Robidart, Julie C, Sarma, Vedula VSS, Sato, Takuya, Saxena, Himanshu, Selden, Corday, Seymour, Justin R, Shi, Dalin, Shiozaki, Takuhei, Singh, Arvind, Sipler, Rachel E, Sun, Jun, Suzuki, Koji, Takahashi, Kazutaka, Tan, Yehui, Tang, Weiyi, Tremblay, Jean-Éric, Turk-Kubo, Kendra, Wen, Zuozhu, White, Angelicque E, Wilson, Samuel T, Yoshida, Takashi, Zehr, Jonathan P, Zhang, Run, Zhang, Yao, and Luo, Ya-Wei

Subjects
Life Below Water, Atmospheric Sciences, Geochemistry, Physical Geography and Environmental Geoscience
Abstract

Abstract. Marine diazotrophs convert dinitrogen (N2) gas intobioavailable nitrogen (N), supporting life in the global ocean. In 2012, thefirst version of the global oceanic diazotroph database (version 1) waspublished. Here, we present an updated version of the database (version 2),significantly increasing the number of in situ diazotrophic measurements from13 565 to 55 286. Data points for N2 fixation rates, diazotrophic cellabundance, and nifH gene copy abundance have increased by 184 %, 86 %, and809 %, respectively. Version 2 includes two new data sheets for the nifH genecopy abundance of non-cyanobacterial diazotrophs and cell-specific N2fixation rates. The measurements of N2 fixation rates approximatelyfollow a log-normal distribution in both version 1 and version 2. However,version 2 considerably extends both the left and right tails of thedistribution. Consequently, when estimating global oceanic N2 fixationrates using the geometric means of different ocean basins, version 1 andversion 2 yield similar rates (43–57 versus 45–63 Tg N yr−1; rangesbased on one geometric standard error). In contrast, when using arithmeticmeans, version 2 suggests a significantly higher rate of 223±30 Tg N yr−1 (mean ± standard error; same hereafter) compared to version 1(74±7 Tg N yr−1). Specifically, substantial rate increases areestimated for the South Pacific Ocean (88±23 versus 20±2 Tg N yr−1), primarily driven by measurements in the southwestern subtropics,and for the North Atlantic Ocean (40±9 versus 10±2 Tg N yr−1). Moreover, version 2 estimates the N2 fixation rate in theIndian Ocean to be 35±14 Tg N yr−1, which could not be estimatedusing version 1 due to limited data availability. Furthermore, a comparisonof N2 fixation rates obtained through different measurement methods atthe same months, locations, and depths reveals that the conventional15N2 bubble method yields lower rates in 69 % cases compared tothe new 15N2 dissolution method. This updated version of thedatabase can facilitate future studies in marine ecology andbiogeochemistry. The database is stored at the Figshare repository(https://doi.org/10.6084/m9.figshare.21677687; Shao etal., 2022).

Published
2023

9. Ectopic pregnancy : models and medical management

Author

Campbell, Lisa L., Horne, Andrew, Gray, Nicola, and Hannan, Natalie

Subjects
ectopic pregnancy, diagnosis, methotrexate efficacy, adenosine, cetrorelix
Abstract

Ectopic pregnancy, derived from the Greek "ektopos" meaning 'out-of-place', describes a pregnancy where the conceptus implants and develops at an abnormal location, most commonly the Fallopian tube. It complicates 1-2% of all pregnancies and is life-threatening due to aberrant placental trophoblast invasion of maternal blood vessels, which can result in catastrophic intra-abdominal haemorrhage. Until the 21st century, the only treatment option was surgical, in most instances involving removal of the tube containing the pregnancy. Following advances in ultrasound and the introduction of quantitative serum measurement of human chorionic gonadotrophin (hCG), it is now possible to select 'lower risk' cases where it is safe to offer expectant monitoring (until spontaneous resolution) or medical management. Medical treatment, with the chemotherapeutic methotrexate, can be offered to 40% of women presenting with an ectopic pregnancy. However, the efficacy of methotrexate is such that it is only offered to women presenting with low hCG levels; a group in which reported success rates, time-to-resolution and risk of haemorrhage are similar to that of expectant monitoring. There is consequently a clinical need to develop more efficacious and less toxic medical therapies for ectopic pregnancy. Further advances in therapy require development of experimental model systems to allow pre-clinical testing of drugs and to improve understanding of the pathophysiology of this condition; the latter traditionally limited by the fundamental difficulty in differentiating cause from effect in ex vivo specimens. Using in vitro and in vivo systems, this thesis investigates: 1) new potential experimental models of ectopic pregnancy; 2) methotrexate's mechanism of action at the level of the trophoblast in the treatment of ectopic pregnancy; and 3) use of gonadotrophin releasing hormone (GnRH) receptor antagonists as a new medical treatment for ectopic pregnancy. To develop an in vivo model of ectopic pregnancy, mouse blastocysts, hatched from the zona pellucida, were transferred to oviducts of recipient mice. I found, due to murine embryos inherent ability to undergo embryonic diapause (a phenomenon not seen in humans) that this process did not result in ectopic implantation. I was able to generate an in vitro model of ectopic pregnancy, where mouse blastocysts attached to human Fallopian tube cells at low frequency (in comparison to the high numbers of blastocysts which attach to endometrial cells). This mirrors the in vivo situation where ectopic implantation occurs in a minority of pregnancies. Manipulation of this system could offer new insights into the pathogenesis of ectopic pregnancy. The extravillous trophoblast (EVT) cells of an ectopic embryo, which invade the maternal Fallopian tube, are a therapeutic target in ectopic pregnancy. EVT cell lines are routinely used in placental research but there is some disagreement in the literature as to how closely they represent primary EVT cells. In my routine assessment of EVT cell lines for use in this thesis, I unexpectedly identified co-expression of cytokeratin 7 (an epithelial marker, traditionally used as a trophoblast marker) with vimentin (a mesenchymal marker, traditionally used to demonstrate non-trophoblastic origin). This suggests these cells may have retained the ability to undergo partial epithelial mesenchymal transition, a characteristic of the primary cells from which they are derived. It is widely presumed that the mechanism of action of methotrexate in ectopic pregnancy is inhibition of DNA synthesis, as is the case where it is used at a 20-fold higher dose in the treatment of certain cancers. However, in vitro replication of maternal serum concentrations achieved following treatment with the low dose of methotrexate used in ectopic pregnancy, demonstrated only mild inhibition of cell cycle progression in just one of three EVT cell lines tested. In contrast, persistently high methotrexate concentrations, which more closely replicate cancer therapy, were able to inhibit DNA synthesis. Countertherapeutically, methotrexate was noted to increase trophoblast production of the pro-pregnancy hormones, hCG and progesterone. In rheumatoid arthritis, a different mechanism of action for methotrexate has been identified secondary to the extracellular accumulation of the anti-inflammatory nucleoside adenosine. I showed that EVT cell lines express adenosine receptors and secrete adenosine, both of which are stimulated by treatment with methotrexate. What role this may have in treatment of ectopic pregnancy requires future investigation. Gonadotrophin releasing hormone (GnRH) is a peptide that acts via its G-protein coupled receptor (GnRHR) as a central regulator of the hypothalamic-pituitary-gonadal axis. GnRHR antagonists are used routinely in artificial reproductive technologies. The GnRHR is also expressed in some reproductive cancers, where antagonism inhibits proliferation and invasion, and in some peripheral tissues including the EVT cells of ectopic pregnancies. I have shown that GnRHR antagonists inhibit trophoblast proliferation and hCG production in vitro. In mouse pregnancy, the effect of GnRHR antagonism was gestation dependent, with treatment at e9.5 causing fetal growth restriction and increased mid-gestation fetal loss, and treatment at e7.5 inducing 100% litter loss. This pre-clinical study suggests that GnRHR antagonists could have utility as a future treatment for ectopic pregnancy. In conclusion, this thesis describes a novel in vitro model of ectopic pregnancy; identifies that the mechanism of action of methotrexate in ectopic pregnancy is not as presumed, perhaps explaining its limited efficacy; and that pre-clinical study of GnRHR antagonists suggest they may represent a promising new medical treatment for ectopic pregnancy.

Published
2023
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11. List of contributors

Author

Al-Kandari, Manal, primary, Allen, Andrew E., additional, Alves-de-Souza, Catharina, additional, Baird, Mark, additional, Berges, John A., additional, Bodrossy, Levente, additional, Bolch, Christopher J.S., additional, Bowler, Chris, additional, Bracher, Astrid, additional, Brewin, Robert J.W., additional, Burford, Michele A., additional, Campbell, Lisa, additional, Ciotti, Aurea M., additional, Clément, Alejandro, additional, Clementson, Lesley A., additional, Correa, Nicole, additional, Countway, Peter D., additional, Coyne, Kathryn J., additional, Craw, Pascal, additional, Dutkiewicz, Stephanie, additional, Gaonkar, Chetan C., additional, Garczarek, Laurence, additional, Gérikas Ribeiro, Catherine, additional, Greenlee, Sydney M., additional, Gutiérrez-Rodríguez, Andres, additional, Harke, Matthew J., additional, Henrichs, Darren W., additional, Hickman, Anna, additional, Highfield, Andrea, additional, Hirata, Takafumi, additional, Hook, Sharon E., additional, Ibarbalz, Federico M., additional, Kolody, Bethany C., additional, Kostadinov, Tihomir S., additional, Krock, Bernd, additional, Lopes dos Santos, Adriana, additional, Marcus, Lara, additional, Mardones, Jorge I., additional, McGregor, Glenn B., additional, Mongin, Mathieu, additional, Mouw, Colleen B., additional, Nagai, Satoshi, additional, Neilan, Brett A., additional, Nodder, Scott D., additional, Ong, Denise, additional, Organelli, Emanuele, additional, Paredes-Mella, Javier, additional, Richardson, Anthony, additional, Schroeder, Declan, additional, Sendall, Barbara C., additional, Shi, Xiao Li, additional, Silva, Sebastian, additional, Skerratt, Jennifer, additional, Smith, Matthew C., additional, Soja-Wozniak, Monika, additional, Stern, Rowena, additional, Steven, Andrew D.L., additional, Taylor, Alison R., additional, Thamatrakoln, Kimberlee, additional, Vaulot, Daniel, additional, Vezzulli, Luigi, additional, Vincent, Flora, additional, Von Dassow, Peter, additional, Wang, Yanfei, additional, Wild-Allen, Karen, additional, Willis, Anusuya, additional, Wood, Susanna A., additional, Woodhouse, Jason N., additional, Yarimizu, Kyoko, additional, and Young, Erica B., additional

Published
2022
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12. NCOG-36. IMPACT OF COLLAGEN TILE BRACHYTHERAPY AS TREATMENT FOR RECURRENT GLIOBLASTOMAS ON FUNCTIONAL STATUS AND QUALITY OF LIFE

Author

Garcia, Michael, primary, Brachman, David, additional, Lee, Stuart, additional, Peach, Matthew Sean, additional, Wanebo, John, additional, Smith, Kris, additional, Chen, Clark, additional, Kotecha, Rupesh, additional, Ahluwalia, Manmeet, additional, Hanft, Simon, additional, Nowlan, Adam, additional, McCracken, David, additional, Floyd, John, additional, Shah, Mitesh, additional, Richardson, Angela, additional, Patel, Toral, additional, Pham, Huong, additional, Ryan, Robert, additional, Wasilewski, Andrea, additional, Shen, Colette, additional, Robin, Adam, additional, Ranjan, Tulika, additional, Bojanowski-Hoang, Kimberly, additional, DiNapoli, Vincent, additional, Chamoun, Roukoz, additional, Choutka, Ondrej, additional, Mercado, Catherine, additional, Haydon, Devon, additional, Leng, Lewis, additional, Rodriguez, Analiz, additional, Deb, Nimisha, additional, Patel, Akash, additional, Piccioni, David, additional, Campbell, Lisa, additional, Patel, Sita, additional, and Hall, Angela, additional

Published
2023
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13. CTNI-19. RESECTION AND CESIUM-131 RADIATION SOURCES IMBEDDED IN BIO-RESORBABLE COLLAGEN TILES (GAMMATILE™) FOLLOWED BY THE STUPP PROTOCOL IN NEWLY-DIAGNOSED GLIOBLASTOMA: GESTALT TRIAL-IN-PROGRESS UPDATE

Author

Dunbar, Erin, primary, Nowlan, Adam, additional, McCracken, David, additional, Fink, Karen, additional, Lewis, Luke, additional, Hoeprich, Mark, additional, Lee, Stuart, additional, Paravati, Anthony, additional, Tuncer, Tolga, additional, David, John, additional, Mella, Divya, additional, Aboud, Orwa, additional, Fragoso, Ruben, additional, Bloch, Orin, additional, Ferreira, Clara, additional, Dusenbery, Kathryn, additional, Peach, Matthew Sean, additional, Chang, Eric, additional, Brachman, David, additional, Campbell, Lisa, additional, and Chen, Clark, additional

Published
2023
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19. World-making through mapping

Author

Campbell, Lisa M., primary, Gray, Noella J., additional, Zigler, Sarah Bess Jones, additional, Acton, Leslie, additional, and Gruby, Rebecca, additional

Published
2021
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21. Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints in Cancer Clinical Trials-Innovative Medicines Initiative (SISAQOL-IMI): stakeholder views, objectives, and procedures

Author

Pe, Madeline, primary, Alanya, Ahu, additional, Falk, Ragnhild Sorum, additional, Amdal, Cecilie Delphin, additional, Bjordal, Kristin, additional, Chang, Jane, additional, Cislo, Paul, additional, Coens, Corneel, additional, Dirven, Linda, additional, Speck, Rebecca M, additional, Fitzgerald, Kristina, additional, Galinsky, Jayne, additional, Giesinger, Johannes M, additional, Holzner, Bernhard, additional, Le Cessie, Saskia, additional, O'Connor, Daniel, additional, Oliver, Kathy, additional, Pawar, Vivek, additional, Quinten, Chantal, additional, Schlichting, Michael, additional, Ren, Jinma, additional, Roychoudhury, Satrajit, additional, Taphoorn, Martin J B, additional, Velikova, Galina, additional, Wintner, Lisa M, additional, Griebsch, Ingolf, additional, Bottomley, Andrew, additional, Bui, Cat, additional, Emechebe, Nnadozie, additional, Kamalakar, Rajesh, additional, Papadopoulos, Elektra, additional, Sail, Kavita, additional, Sen, Rohini, additional, Turner, Sean C, additional, Cocks, Kim, additional, Reijneveld, Jaap, additional, Gerlinger, Christoph, additional, Keating, Karen, additional, Su, Yun, additional, Wolf, Birgit, additional, Ge, Miaomiao, additional, Ingelgaard, Anders, additional, Peil, Barbara, additional, Voorhaar, Maarten, additional, Wong, Brendon, additional, Dekanic Arbanas, Gracia, additional, Kuljanic, Karin, additional, Petranovic, Duska, additional, Rede, Ivana, additional, Arraras, Juan, additional, Coons, Stephen Joel, additional, Eremenco, Sonya, additional, Murray, Lindsey, additional, Reeve, Bryce, additional, De Vries, Corinne, additional, Herold, Ralf, additional, Pignatti, Francesco, additional, Machingura, Abigirl, additional, Martinelli, Francesca, additional, Musoro, Jammbe, additional, Piccart, Martine, additional, Barriuso, Jorge, additional, Cherny, Nathan, additional, Dafni, Ourania, additional, De Vries, Elisabeth, additional, Gyawali, Bishal, additional, Kiesewetter, Barbara, additional, Oosting, Sjoukje, additional, Roitberg, Felipe, additional, Rumpold, Gerhard, additional, Schoepf, Felix, additional, Tschuggnall, Michael, additional, Black, Jennifer, additional, Sasseville, Maxime, additional, Soltys, Katherine, additional, Ferrer, Montserrat, additional, Garin, Olatz, additional, Vilagut, Gemma, additional, Schürmann, Christoph, additional, Thomas, Stefanie, additional, Wieseler, Beate, additional, Snyder, Claire, additional, Alonso Abad, Ariel, additional, Bogaerts, Kris, additional, Brackx, Febe, additional, Molenberghs, Geert, additional, Verbeke, Geert, additional, Frigolett Catalan, Cristián, additional, Choi, Jan, additional, Thomassen, Doranne, additional, Geissler, Jan, additional, Sauerbrei, Willi, additional, Gross, Franziska, additional, Pilz, Micha Johannes, additional, Barbachano, Yolanda, additional, Campbell, Lisa, additional, Rantell, Khadija, additional, Desplanques, Gregoire, additional, Regnault, Antoine, additional, Morgan, Kate, additional, Plate, Ananda, additional, ten Seldam, Silene, additional, Terada, Mitsumi, additional, Mizusawa, Junki, additional, Mitchell, Sandra, additional, Wilder Smith, Ashley, additional, Reksten, Tove Ragna, additional, Schiel, Anja, additional, Hansen Joseph, Kenth Louis, additional, Campbell, Alicyn, additional, Cappelleri, Joseph, additional, de Besi, Patrizia, additional, Russell-Smith, Alexander, additional, Sandin, Rickard, additional, Mamolo, Carla, additional, Brundage, Michael, additional, Tu, Dongsheng, additional, Groenvold, Mogens, additional, Petersen, Morten, additional, Cleeland, Charlie, additional, Williams, Lori, additional, Shelley Wang, Xin, additional, Ringash, Jolie, additional, Calvert, Melanie, additional, Cruz Rivera, Samantha, additional, Aiyegbusi, Olalekan Lee, additional, Goetghebeur, Els, additional, Liu, Limin, additional, Van Lancker, Kelly, additional, Boele, Florien, additional, Gilbert, Alexandra, additional, Peacock, Rosemary, additional, Basch, Ethan, additional, King, Madeleine, additional, Rutherford, Claudia, additional, Bhatnagar, Vishal, additional, Fiero, Mallorie, additional, Horodniceanu, Erica, additional, Johnson, Laura Lee, additional, Kluetz, Paul, additional, and Rodriguez, Lisa, additional

Published
2023
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22. How academic podcasting can change academia and its relationship with society: A conversation and guide

Author

Cox, Michael, primary, Harrison, Hannah L., additional, Partelow, Stefan, additional, Curtis, Steven, additional, Elser, Stephen R., additional, Hammond Wagner, Courtney, additional, Hobbins, Robert, additional, Barnes, Conor, additional, Campbell, Lisa, additional, Cappelatti, Laura, additional, De Sousa, Emily, additional, Fowler, Julie, additional, Larson, Erin, additional, Libertson, Frans, additional, Lobo, Rafaella, additional, Loring, Philip, additional, Matsler, Marissa, additional, Merrie, Andrew, additional, Moody, Eric, additional, Quiñones, Rubi, additional, Sauer, Jason, additional, Shabb, Katherine, additional, Hauge Simonsen, Sturle, additional, Washko, Susan, additional, and Whittaker, Ben, additional

Published
2023
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24. Church Matters

Author

Campbell, Cathy L., primary, Williams, Ishan C., additional, and Campbell, Lisa C., additional

Published
2023
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26. A survey of Dinophysis spp. and their potential to cause diarrhetic shellfish poisoning in coastal waters of the United States

Author

Ayache, Nour, primary, Bill, Brian D., additional, Brosnahan, Michael L., additional, Campbell, Lisa, additional, Deeds, Jonathan R., additional, Fiorendino, James M., additional, Gobler, Christopher J., additional, Handy, Sara M., additional, Harrington, Neil, additional, Kulis, David M., additional, McCarron, Pearse, additional, Miles, Christopher O., additional, Moore, Stephanie K., additional, Nagai, Satoshi, additional, Trainer, Vera L., additional, Wolny, Jennifer L., additional, Young, Craig S., additional, and Smith, Juliette L., additional

Published
2023
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28. SPIRIT-PRO Extension explanation and elaboration: guidelines for inclusion of patient-reported outcomes in protocols of clinical trials.

Author

Calvert, Melanie, King, Madeleine, Mercieca-Bebber, Rebecca, Aiyegbusi, Olalekan, Kyte, Derek, Slade, Anita, Chan, An-Wen, Basch, E, Bell, Jill, Bennett, Antonia, Bhatnagar, Vishal, Blazeby, Jane, Bottomley, Andrew, Brown, Julia, Brundage, Michael, Campbell, Lisa, Cappelleri, Joseph C, Draper, Heather, Dueck, Amylou C, Ells, Carolyn, Frank, Lori, Golub, Robert M, Griebsch, Ingolf, Haywood, Kirstie, Hunn, Amanda, King-Kallimanis, Bellinda, Martin, Laura, Mitchell, Sandra, Morel, Thomas, Nelson, Linda, Norquist, Josephine, O'Connor, Daniel, Palmer, Michael, Patrick, Donald, Price, Gary, Regnault, Antoine, Retzer, Ameeta, Revicki, Dennis, Scott, Jane, Stephens, Richard, Turner, Grace, Valakas, Antonia, Velikova, Galina, von Hildebrand, Maria, Walker, Anita, and Wenzel, Lari

Subjects
Humans, Research Design, Quality of Life, Checklist, Research Report, Patient Reported Outcome Measures, clinical trials, education & training, protocols & guidelines, statistics & research methods, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on the impact of disease and treatment on patients' symptoms, function and quality of life. High-quality PRO data from trials can inform shared decision-making, regulatory and economic analyses and health policy. Recent evidence suggests the PRO content of past trial protocols was often incomplete or unclear, leading to research waste. To address this issue, international, consensus-based, PRO-specific guidelines were developed: the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT)-PRO Extension. The SPIRIT-PRO Extension is a 16-item checklist which aims to improve the content and quality of aspects of clinical trial protocols relating to PRO data collection to minimise research waste, and ultimately better inform patient-centred care. This SPIRIT-PRO explanation and elaboration (E&E) paper provides information to promote understanding and facilitate uptake of the recommended checklist items, including a comprehensive protocol template. For each SPIRIT-PRO item, we provide a detailed description, one or more examples from existing trial protocols and supporting empirical evidence of the item's importance. We recommend this paper and protocol template be used alongside the SPIRIT 2013 and SPIRIT-PRO Extension paper to optimise the transparent development and review of trial protocols with PROs.

Published
2021

34. The opportunity for greater patient and public involvement and engagement in drug development and regulation

Author

Aiyegbusi, Olalekan Lee, primary, Cruz Rivera, Samantha, additional, Oliver, Kathy, additional, Manna, Elaine, additional, Collis, Phil, additional, King-Kallimanis, Bellinda L., additional, Bhatnagar, Vishal, additional, Herold, Ralf, additional, Hopkins, Jon, additional, Campbell, Lisa, additional, Croker, Alysha, additional, Leach, Myles, additional, and Calvert, Melanie J., additional

Published
2023
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38. Antiracism CoaliTION in Pain Research (ACTION-PR): Guiding Principles for Equity in Reporting

Author

Hood, Anna M., primary, Morais, Calia A., additional, Aroke, Edwin N., additional, Booker, Staja Q., additional, Campbell, Lisa C., additional, Campbell, Claudia M., additional, Goodin, Burel R., additional, Janevic, Mary R., additional, Kapos, Flavia P., additional, Mathur, Vani A., additional, Merriwether, Ericka N., additional, and Letzen, Janelle E., additional

Published
2023
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48. Trends in Dinophysis abundance and diarrhetic shellfish toxin levels in California mussels (Mytilus californianus) from Monterey Bay, California

Author

Shultz, Dana, Campbell, Lisa, and Kudela, Raphael M

Subjects
Animals, Bays, California, Dinoflagellida, Humans, Marine Toxins, Mytilus, Shellfish, Washington, Dinophysis, Diarrhetic shellfish toxin, Okadaic acid, Monterey Bay, Dinoflagellate, Harmful algal bloom, Environmental Sciences, Biological Sciences, Marine Biology & Hydrobiology
Abstract

Diarrhetic shellfish toxins (DSTs) are produced by the marine dinoflagellate, Dinophysis, as well as select species of benthic Prorocentrum. The DSTs can bioaccumulate in shellfish and cause gastrointestinal illness when humans consume high levels of this toxin. Although not routinely monitored throughout the U.S., recent studies in Washington, Texas, and New York suggest DSTs may be widespread throughout U.S. coastal waters. This study describes a four-year time series (2013-2016) of Dinophysis concentration and DST level in California mussels (Mytilus californianus) from Santa Cruz Municipal Wharf (SCMW) in Monterey Bay, California. Results show a maximum Dinophysis concentration of 9404 cells/L during this study and suggest Dinophysis persists as a member of the background phytoplankton community throughout the year. In California mussels, DSTs were found at persistent low levels throughout the course of this study, and exceeded the FDA guidance level of 160 ng/g 19 out of 192 weeks sampled. Concentrations of Dinophysis alone are a positive but weak predictor of DST level in California mussels, and basic environmental variables (temperature, salinity, and nutrients) do not sufficiently explain variation in Dinophysis concentration at SCMW. This study demonstrates that Dinophysis in Monterey Bay are producing DSTs that accumulate in local shellfish throughout the year, occasionally reaching levels of concern.

Published
2019

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